环黄芪醇Cycloastragenol 98% 陕西永源生物 CAS号：84605-18-5

Cycloastragenol

陕西更新日期：2017-10-10

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中文名称：: 环黄芪醇Cycloastragenol 98% 陕西永源生物 CAS号：84605-18-5

英文名称：: Cycloastragenol

CAS号：: 84605-18-5

产地：: 中国

纯度规格：: 98%

产品名称：环黄芪醇Cycloastragenol

提取来源：豆科植物蒙古黄芪 Astragalus membranaceus （Fisch.）Bge. var.mongholicus （Bge）Hsiao或 Astragalus membranaceus （Fisch.）Bge.的干燥根。

产品规格：98% HPLC-ELSD

CAS号：84605-18-5

分子式：C30H50O5

分子量：490.72

主要应用：环黄芪醇（Cycloastragenol）是从豆科植物蒙古黄芪Astragalus membranaceus(Fisch．)Bge．var．mongholicus(I Hsiao或膜荚黄芪Astragalus mernbranaceus(Fiseh．)Bge．的干燥根中直接提取分离或由黄芪甲苷（Astragaloside Ⅳ）的水解得到，具有增强机体免疫力、清除自由基、保护心肌细胞、增强心肌活力，减轻心肌缺血、抗心力衰竭等作用。其机制是通过抑制磷酸二酯酶的活性，使环磷腺苷(cAMP)分解减少，心肌细胞中 cAMP浓度增加，促进肌浆网内钙离子的释放，从而使心肌细胞的兴奋-收缩偶联活动加。黄芪还能改善血液流变学，降低血液粘滞度，减轻心脏负荷。在中国临床应用多年的中成药“黄芪口服液”、中药注射剂“黄芪注射液”中的主要成分即是Astragaloside Ⅳ，“黄芪注射液”主要用于治疗病毒性心肌炎、心功能不全及肝炎等疾病。“黄芪口服液”主要用于治疗病毒性肝炎、和提高机体免疫力、抗疲劳等。
最近，黄芪甲苷和环黄芪醇的作用机理研究已有了突破性的进展。特别是美国Geron 生物技术公司的研究发现了黄芪甲苷及其苷原环黄芪醇主要是通过激活Telomerase而发挥其生物学作用，对以黄芪甲苷和环黄芪醇为基础的新药和新保健品的研究开发起到了积极的推动作用。

包装：1公斤/铝箔袋；或根据客户需求

保存：置于阴凉干燥、避光，避高温处

有效期： 24个月

Product name: Cycloastragenol

Botanical source: Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge) Hsiao or Astragalus menbranaceus (Fisch.) Bge.

Specification: 90% 98%

Test Method: HPLC-ELSD

CAS No.: 84605-18-5

Molecular Formula: C30H50O5

Molecular Weight: 490.72

Function:

Cycloastragenol is a sapogenin found in or derived from Astragalus membranaceus. It seems to moderately increase telomerase activity and proliferative capacity in both CD4 and CD8 T cells in in vitro experiments. Cycloastragenol is extracted and purified from the roots of Astragalus membranaceus, being claimed to stimulate immune system, to improve cardiovascular health, and to repair DNA.

Cycloastragenol has a similar chemical structure to that of the Astragaloside IV molecule, but it is smaller and significantly more bioavailable, enabling lower doses to be taken. It is already used as an immunostimulant because of its ability to increase T lymphocyte proliferation. However, it is its exceptional anti-aging properties that are of increasing interest to the scientific community. Cycloastragenol stimulates the repair of DNA damage by activating telomerase, a nucleoprotein enzyme which catalyses synthesis and growth of telomeric DNA. Telomeres are made of thin filaments and are found at the tips of chromosomes. Maintaining their stability enables cells to avoid replicative senescence and indefinite proliferation beyond the ‘Hayflick limit’. Telomeres shorten with each cycle of cell division, or when subjected to oxidative stress. Until now, this has been an unavoidable mechanism of aging.

Storage: Store in sealed containers at cool & dry place. Protect from light, moisture and pest infestation

Shelf life: 2 years when properly stored.

Packing: 1KG/Aluminum foil.

环黄芪醇, Cycloastragenol, CAS No.: 84605-18-5