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网站主页 AKT1, HUMAN, 重组蛋白 (HIS) AKT1, Human, 重组蛋白 (His)
  • AKT1, Human, 重组蛋白 (His)|TMPY-04552|TargetMol

AKT1, Human, 重组蛋白 (His)|TMPY-04552|TargetMol

AKT1 Protein, Human, Recombinant (His)
585 5μg 起订
上海 更新日期:2026-05-08

TargetMol 中国(陶术生物)

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联系人:邵经理
电话:400-821-0310拨打
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邮箱:xuexiang.shao@tsbiochem.com

产品详情:

中文名称:
AKT1, Human, 重组蛋白 (His)
英文名称:
AKT1 Protein, Human, Recombinant (His)
品牌:
TargetMol
产地:
美国
保存条件:
Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
产品类别:
抑制剂
种属:
Human
表达系统:
Baculovirus Insect Cells
蛋白长度:
A DNA sequence encoding the human AKT1 (NP_001014431.1) (Met 1-Ala 480) was fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Met 1
标签:
C-His
货号:
T011|TMPY-04552

Product Introduction

Bioactivity

名称AKT1 Protein, Human, Recombinant (His)
描述v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to insulin, insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. AKT1 activity is required for physiologic cardiac growth in response to IGF1 stimulation or exercise training. In contrast, AKT1 activity was found to antagonize pathologic cardiac growth that occurs in response to endothelin 1 stimulation or pressure overload. AKT1 selectively promotes physiological cardiac growth while AKT2 selectively promotes insulin-stimulated cardiac glucose metabolism. AKT1 deletion prevented tumor initiation as well as tumor progression, coincident with decreased Akt signaling in tumor tissues. AKT1 is the primary Akt isoform activated by mutant K-ras in lung tumors, and that AKT3 may oppose AKT1 in lung tumorigenesis and lung tumor progression. A number of separate studies have implicated AKT1 as an inhibitor of breast epithelial cell motility and invasion. AKT1 may have a dual role in tumorigenesis, acting not only pro-oncogenically by suppressing apoptosis but also anti-oncogenically by suppressing invasion and metastasis.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
存储条件Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
关键字CWS-6 | CWS 6
v-akt murine thymoma viral oncogene homolog 1;RAC-α;RAC-ALPHA;RAC;PRKBA;PKB-α;PKB-ALPHA;PKB;CWS6;AKT;TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ¥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

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