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网站主页 P53, MOUSE, 重组蛋白 (HIS & SUMO) p53, Mouse, 重组蛋白 (His & SUMO)
  • p53, Mouse, 重组蛋白 (His & SUMO)|TMPH-02574|TargetMol

p53, Mouse, 重组蛋白 (His & SUMO)|TMPH-02574|TargetMol

p53 Protein, Mouse, Recombinant (His & SUMO)
3760 100μg 起订
上海 更新日期:2026-05-08

TargetMol 中国(陶术生物)

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产品详情:

中文名称:
p53, Mouse, 重组蛋白 (His & SUMO)
英文名称:
p53 Protein, Mouse, Recombinant (His & SUMO)
品牌:
TargetMol
产地:
美国
保存条件:
Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
纯度规格:
90.00%
产品类别:
抑制剂
重组:
种属:
Mouse
表达物种:
Mouse
蛋白长度:
1-387 aa
标签:
N-6xHis-SUMO
修饰:
N-6xHis-SUMO
UniProt ID:
P02340
PubChem CID:
P02340
缓冲液:
Tris-based buffer, 50% glycerol
表达系统:
E. coli
货号:
T011|TMPH-02574

Product Introduction

Bioactivity

名称p53 Protein, Mouse, Recombinant (His & SUMO)
描述Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2. However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis, but seems to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.
存储条件Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
关键字Trp 53 | Tp 53 | P 53
Tumor suppressor p53;Trp53;Tp53;P53;Cellular tumor antigen p53;TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ¥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

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