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  • 化合物 PQ401 hydrochloride|T4324|TargetMol

化合物 PQ401 hydrochloride|T4324|TargetMol

PQ401 hydrochloride (196868-63-0(free base))
￥139 2mg 起订
￥277 5mg 起订
￥386 10mg 起订
上海 更新日期：2026-05-08

TargetMol中国（陶术生物）

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联系人：邵经理
电话：400-821-0310拨打
手机：15002144251 拨打
邮箱：xuexiang.shao@tsbiochem.com

产品详情:

中文名称：
化合物 PQ401 hydrochloride
英文名称：
PQ401 hydrochloride (196868-63-0(free base))
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
纯度规格：
99.90%
产品类别：
抑制剂
货号：
T4324

Product Introduction

Bioactivity

名称PQ401 hydrochloride (196868-63-0(free base))
描述PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.
细胞实验Cell lines: MCF-7,MCNeuA. Concentrations: ~50 μM. Incubation Time: 3 days. Method: The inhibitory effects of diaryl urea on breast cancer cell growth are determined using a CyQuant cell proliferation assay kit.MCF-7 or MCNeuA cells are plated in 96-well plates (5×103 per well) in phenol red-free DMEM supplemented with 10% FCS.One plate isprepared for each harvest day.Cells are allowed to adhere overnight and are then treated with various concentrations of diaryl urea or DMSO as a vehicle control.Microplate cultures are harvested on days 0,1,2,and 3 by inverting the microplate onto paper towels with gentle blotting to remove growth medium without disrupting adherent cells.Each plate iskept at ?80 ℃ until the end of the experiment (day 3) when all of the plates are thawed and assayed together.After thawing,200 μL of CyQuant GR solution are added to each well and the plates are incubated in the dark for 2 to 5 minutes.Fluorescence ismeasured with a SpectraMax Gemini XS fluorescence microplate reader with 480-nm excitation and 520-nm emission.Proliferation index iscalculated as the percent of nucleotide content versus control cells at day 0.
激酶实验IGF-IR Peptide Autophosphorylation:One microgram of constitutively active IGF-IR kinase domain peptide isincubated +/? varying concentrations of PQ 401 in 2% DMSO in 40 mM Tris (pH 7.4), 80 μMEGTA, 0.25% 2-mercaptoethanol, 80 μM Na3VO4, 10 mM MgCl2, and 2 mM MnCl2 for 20 minutes. ATP is then added at a final concentration of 20 μM. Autophosphorylation of the kinase domain peptide isallowed to occur for 20 minutes at 22℃. The reaction isstopped by the addition of SDS-reducing buffer and the samples are run on SDS-PAGE. Following transfer to nitrocellulose membrane, peptide autophosphorylation isdetermined by Western blotting employing an antibody against phosphotyrosine (PY20).
动物实验Animal Models: FVB/N-TgN(MMTVneu)202 mouse injected with MCNeuA cells. Formulation: 8% polysorbate 80 and ethanol. Dosages: 50 or 100 mg/kg. Administration: i.p.
体外活性PQ 401 是一种 IGF-1R 抑制剂，可在小于100 nM 的浓度下抑制 IGF-1R 激酶域的自磷酸化，IC50 值小于1 μM。PQ 401 显著降低了 MCF-7 细胞的增殖，IC50 为8 μM；同时，PQ 401 也能够抑制 MCNeuA 细胞的增长，IC50 为15 μM。此外，PQ 401 抑制了 MCF-7 细胞中 IGF-I介导的抗凋亡途径，并增加了 MCF-7 细胞中的 caspase 介导的凋亡活性。
体内活性PQ 401（50 mg/Kg、100 mg/Kg）显著且剂量依赖性地抑制了MCNeuA肿瘤的生长。
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
溶解度DMSO : 45 mg/mL (118.97 mM), Sonication is recommended.
关键字PQ401 hydrochloride (196868-63-0(free base)) | PQ-401 hydrochloride (196868-63-0(free base)) | PQ401 hydrochloride (196868630(free base)) | PQ401 hydrochloride (196868 63 0(free base)) | IGF-1R | IGF1R
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PQ401 hydrochloride (196868-63-0(free base))|TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

化合物 PQ401 hydrochloride相关厂家报价 更多

  • 黄芪甲苷
  • 黄芪甲苷
  • 成都格利普生物科技有限公司 VIP
  • 2026-05-08
  • ￥150
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