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网站主页 化工产品目录 原料药 抗寄生虫病药 抗疟药 二盐酸奎吖因水合物 化合物 Quinacrine (dihydrochloride hydrate)
  • 化合物 Quinacrine (dihydrochloride hydrate)|T23210|TargetMol

化合物 Quinacrine (dihydrochloride hydrate)|T23210|TargetMol

Quinacrine (dihydrochloride hydrate)
￥325 100mg 起订
￥430 500mg 起订
上海 更新日期：2026-05-08

TargetMol 中国（陶术生物）

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电话：400-821-0310拨打
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邮箱：xuexiang.shao@tsbiochem.com

产品详情:

中文名称：
化合物 Quinacrine (dihydrochloride hydrate)
英文名称：
Quinacrine (dihydrochloride hydrate)
CAS号：
207671-43-0
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
产品类别：
抑制剂
货号：
T23210

Product Introduction

Bioactivity

名称Quinacrine (dihydrochloride hydrate)
描述Quinacrine is a compound that is commonly used as an anti-protozoal agent. It inhibits voltage-dependent sodium channels (IC50: 3.3 μM) and suppresses aldehyde oxidase (IC50: 3.3 μM). Quinacrine prevents misfolding of prion protein (EC50: 0.3 μM). As an effective riboflavin antagonist, quinacrine associates with the riboflavin-binding protein (Ki: 6.7 μM). Voltage-dependent sodium channels play a vital role in action potential initiation and propagation in excitable cells, including muscle, nerve, and neuroendocrine cell types.
体外活性Quinacrine, in a dose-dependent manner, effectively reversed the resistance in the multi-drug resistance (MDR) K562 cells. Quinacrine displayed strong toxicity to the MDR K562 cells at a concentration of 10.0 μM. Compared to the control, quinacrine significantly increased the activity of caspase-9 and -3 activities in the MDR K562 and K562 cells in a dose-dependent fashion [1].
体内活性Female BALB/c nude mice, bearing MDR K562 cell xenografts, were injected with quinacrine at a dose of 10 mg/kg via tail vein for 13 days. Compared to the control group, quinacrine inhibited tumor growth obviously in the treated groups. Furthermore, quinacrine enhanced the anti-tumor effects of vincristine [1].
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
溶解度H2O : ≥18.65 mg/mL, Sonication is recommended.
关键字Quinacrine (hydrochloride hydrate) | Quinacrine | dihydrochloride Hydrate | 83-89-6 free base | 83-89-6
br
Quinacrine (hydrochloride hydrate) (83-89-6 free base)|TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

化合物 Quinacrine (dihydrochloride hydrate)相关厂家报价 更多

  • 疟疾平
  • 疟疾平
  • 广州贝尔卡生物科技有限公司
  • 2024-03-04
  • 询价
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