乙酰基-(脯氨酸1?,天冬氨酸21)-β-淀粉样蛋白(17-21)酰胺，339990-02-2，iAb5p Pro18 Asp21 新品

Product Name：Ac-[Pro18, Asp21] β- Amyloid (17 - 21), amide, iAb5p Pro18 Asp21

Synonyms：乙酰基-(脯氨酸¹⁸,天冬氨酸²¹)-β-淀粉样蛋白(17-21)酰胺

CAS No.：339990-02-2

Catalog No.：GT-XL0177

Brand：Go Top peptide（杭州固拓）

Description：iAβ5p是β-淀粉样蛋白（Aβ）的修饰肽类似物，作为β-折叠破坏肽，它能够破坏Aβ(1-42)的β-折叠结构、抑制淀粉样纤维形成，同时相比多数蛋白与多肽更易穿透血脑屏障，可通过特异性转运机制进入大脑，并在阿尔茨海默病转基因模型中表现出显著的神经保护作用，能提高神经元存活率、减轻脑内炎症反应。

iAβ5p is a modified peptide analog of β-amyloid (Aβ). As a β-sheet disrupting peptide, it can disrupt the β-sheet structure of Aβ(1-42), inhibit amyloid fibril formation, and, compared to most proteins and peptides, more easily penetrate the blood-brain barrier. It can enter the brain through a specific transport mechanism and shows significant neuroprotective effects in Alzheimer's disease transgenic models, improving neuronal survival and reducing brain inflammation.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H2O/DMSO

Vacuum-packedwith aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

Sequence(1-letter code)	Ac-LPFFD-NH2
Sequence(3-letter code)	Ac-Leu-Pro-Phe-Phe-Asp-NH2
Peptide Structure
Molecular Formula	C35H46N6O8
Molecular Weight	678.77

申明：产品仅供科研使用，不得用于人体。

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