受体拮抗剂多肽CJ-15208/210236-47-8/CJ-15208 新品

Product Name：CJ-15208

CAS No.：210236-47-8

Synonyms：受体拮抗剂多肽CJ-15208

Catalog No.：220P329

Brand：Typeptide Biotech（肽研生物）

Description：CJ-15208是一种强效和选择性的κ-阿片受体拮抗剂多肽，是由四个氨基酸组成的环状多肽，具有显著的阿片活性。CJ-15208在小鼠的温水尾撤回实验中表现出强烈的镇痛效果，并且通过多个阿片受体介导。CJ-15208的立体异构体展现出不同的阿片活性特征，例如一种立体异构体表现出κ-阿片受体拮抗作用，而另一种则表现出δ-阿片受体拮抗作用。CJ-15208的所有立体异构体在呼吸方面没有显著的影响。CJ-15208的立体异构体未导致耐药性的发展，这使其在进一步研发安全的阿片类镇痛药方面具有潜力。

CJ-15208 is a potent and selective κ-opioid receptor antagonist peptide, a cyclic tetrapeptide with significant opioid activity. In mouse tail-flick tests, CJ-15208 demonstrated strong analgesic effects mediated through multiple opioid receptors. The stereoisomers of CJ-15208 exhibit distinct opioid activity profiles, such as one isomer showing κ-opioid receptor antagonism while another exhibits δ-opioid receptor antagonism. None of CJ-15208's stereoisomers significantly affect respiration. The stereoisomers of CJ-15208 did not induce the development of tolerance, highlighting its potential for further development into safe opioid analgesics.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

订购联系方式：

南京肽研生物生物科技有限公司

手机号：19961912513(微信同号)

QQ: 2178255659

邮箱：sales@typeptide.com

联系人：顾经理

申明：本产品仅供科研使用，不得用于人体。