小鼠高灵敏白细胞介素6(IL-6)ELISA试剂盒

小鼠高灵敏白细胞介素6(IL-6)ELISA试剂盒

货号:LM8K2868M

规格:48T/96T

种属:Mouse

范围:.25-400pg/ml

灵敏度:3.75pg/ml

用途:For quantitative detection of IL-6 in serum, plasma, tissue homogenates and other biologicalfluids.

存储:2-8°C

截止日期: see kit label

原理:Sandwich

注意:仅供研究使用。

Background 

Interleukin 6 (IL-6) is a pleiotropic, a-helical, 22-28 kDa phosphorylated and variably glycosylated cytokinethat plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, andcancer progression. IL-6, along with TNF-a and IL-1, drives the acute inflammatory response. IL-6 is almostsolely responsible for fever and the acute phase response in the liver, and it is important in the transitionfrom acute inflammation to either acquired immunity or chronic inflammatory disease. Cells known toexpress IL-6 include CD8+ T cells, fibroblasts, synoviocytes, adipocytes, osteoblasts, megakaryocytes,endothelial cells (under the influence of endothelins), sympathetic neurons, cerebral cortex neurons, adrenalmedulla chromaffin cells, retinal pigment cells, mast cells, keratinocytes, Langerhans cells, fetal and adultastrocytes, neutrophils, monocytes, eosinophils, colonic epithelial cells, and pancreatic islet beta cells. IL -6production is generally correlated with cell activation and is normally kept in control by glucocorticoids,catecholamines, and secondary sex steroids.

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