肌酐(Cr)比色法检测试剂盒(肌氨酸氧化酶法)

肌酐(Cr)比色法检测试剂盒(肌氨酸氧化酶法) 

货号:LM8K911O

规格:48T/96T

种属:Universal

范围:25-800μmol/L

灵敏度:10μmol/L

用途:For quantitative detection of creatinine in serum, plasma and urine.

存储:2-8°C for 12 months

截止日期: see kit label

原理:Enzyme catalysis

注意:仅供研究使用。

BACKROUND

Creatinine is a metabolite of phosphocreatine (p-creatine), a molecule used as a store for highenergyphosphate that can be utilized by tissues for the production of ATP. Creatine either comes from the diet or issynthesized from the amino acids arginine, glycine, and methionine. This occurs in the kidneys and liver,although other organ systems may be involved and species-specific differences may exist. Creatine and pcreatine are converted non-enzymatically to the metabolite creatinine, which diffuses into the blood and isexcreted by the kidneys. In vivo, this conversion appears to be irreversible and in vitro it is favored by highertemperatures and lower pH. Creatinine forms spontaneously from pcreatine, and under normal conditions,its formation occurs at a relatively constant rate. Intra-individual variation of creatinine levels is <15% fromday to day, making it a useful marker for normalizing levels of other molecules found in urine. Alteredcreatinine levels may be associated with conditions that result in decreased renal blood flow, such asdiabetes and cardiovascular disease

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