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MMP2 抗体

品牌：MedChemExpress (MCE)

货号：HY-P85767

存储条件：-20°C保存1年。避免重复冻结/解冻循环。

运输条件：用蓝冰运输。

产品活性：MMP2 Antibody (YA5459) 是一种小鼠来源、无偶联标记、抗 MMP-2 的单克隆抗体。它可用于人、大鼠、小鼠背景下的 WB、IHC-P、ICC/IF 实验。

研究背景：MMP-2 是一种普遍存在的金属蛋白酶，在多种生物过程中发挥多方面的作用，包括脉管系统重塑、血管生成、组织修复、肿瘤侵袭、炎症和动脉粥样硬化斑块破裂。除了降解细胞外基质蛋白的传统作用外，MMP-2 通过作用于大内皮 1 和 β 型 CGRP 等非基质蛋白，从而促进血管收缩，从而表现出多功能性。此外，它在 Gly-|-Leu 键处裂解 KISS，似乎与心肌细胞死亡途径有关，通过调节其在体外裂解的 GSK3beta 活性，导致心肌氧化应激。值得注意的是，MMP-2 的 C 端非催化片段（称为 PEX）具有抗血管生成和抗肿瘤特性，抑制细胞迁移和对 FGF2 和玻连蛋白的粘附，同时作为整合素 α-v/β3 的配体在血管表面。

宿主：Mouse

反应物种：Human, Rat, Mouse

推荐稀释比例：IHC: 1:100-200; WB: 1:500-2000; ICC/IF: 1:50-200 Immunohistochemical analysis of paraffin-embedded rat colon tissue using MMP2 Antibody. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 8 minutes. The tissues were blocked in QuickBlock for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody at 1/100 dilution in 4℃ overnight. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX. Immunohistochemical analysis of paraffin-embedded rat colon tissue using MMP2 Antibody. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 8 minutes. The tissues were blocked in QuickBlock for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody at 1/100 dilution in 4℃ overnight. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.

基因 ID：4313

同用名：MMP2

克隆性：Monoclonal

偶联：Non-conjugated

修饰：Unmodified

蛋白数据库：P08253

详情参考：www.medchemexpress.cn/antibody/mmp-2-antibody-ya5459.html