右旋比扣扣灵碱;(+)-荷包牡丹碱;右旋荷包牡丹碱

Classical GABAA antagonist (+)-Bicuculline(D-Bicuculline;NSC 32192) CAS:485-49-4
右旋比扣扣灵碱;(+)-荷包牡丹碱;右旋荷包牡丹碱; 毕枯枯林;山乌龟碱;比枯枯灵;比扣扣灵;毕枯枯灵.

Product Name: (+)-Bicuculline;D-Bicuculline

Synonyms: D-Bicuculline;(R-(R*,S*))-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-furo(3,4-e)-1,3-benzodioxol-8(6H)-one; (6R)-6-[(5S)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e][1,3]benzodioxol-8(6H)-one; 6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[4,3-g][1,3]benzodioxol-8-one; (5S)-6-methyl-5-[(6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl]-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium; (S)-6-((S)-5,6,7,8-Tetrahydro-6-methyl-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuro[4,5-d][1,3]dioxol-8(6H)-one

CAS No.: 485-49-4

Molecular Formula: C20H17NO6

Molecular Weight: 367.36

Occurrence: Found in Dicentra cucullaria (L.) Bernh., Adlumia fungosa (Ait.) Greene, Fumariaceae, and several Corydalis species.

Appearance: Elongated plates from chloroform-menthanol or pale yellow crystalline powder

Solubility: Soluble in benzene, chloroform, ethyl acetate. Sparingly soluble in alcohol and ether,practically not in water.

Purity by HPLC: >99%

Biological Description: (+)-Bicuculline is GABAA receptor antagonist 

Applications:  Alkaloid naturally occurring in the d-form. Shows GABA antagonist activity.

  Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influence on target neurons. These receptors are the major targets for benzodiazepines and related anxiolytic drugs. Bicuculline is a competitive GABAA receptor antagonist that can act as an allosteric inhibitor at GABAA receptors.At 100 μM, it blocks spontaneously opening chloride channels in the outside-out patches from the cultured cortical neurons. Bicuculline also reversibly blocks GABAA receptors on horizontal cells in the mouse retina with an IC50 value of 1.7 μM.By blocking the inhibitory action of GABA, bicuculline mimics the action of epilepsy and is widely used in experimental studies as a convulsant, inducing seizure in hippocampal or cortical neurons in prepared brain slices.