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ABCC1 蛋白

品牌：MedChemExpress (MCE)

货号：HY-P72069

纯度：Greater than 90% as determined by reducing SDS-PAGE.

产品活性：ABCC1, Human (His) 是一种多任务 ATP 结合盒 (ABC) 转运蛋白。 ABCC1, Human 在炎症和其他免疫疾病、年龄相关性黄斑变性、心血管疾病和某些神经系统疾病以及肿瘤进展中发挥作用。

研究背景：多药耐药蛋白 1（MRP1、ABCC1）是一种多任务 ATP 结合盒 (ABC) 转运蛋白，可能影响许多人类疾病的病因和进展。MRP1 转运多种治疗药物以及多种生理底物，并可能在多种癌症（包括肺癌、乳腺癌和前列腺癌以及儿童神经母细胞瘤）的耐药性发展中发挥作用。越来越多的证据表明，MRP1 是参与神经母细胞瘤多药耐药性发展的 MYCN 靶基因。MRP1 还在炎症和其他免疫性疾病、年龄相关性黄斑变性、心血管疾病和某些神经系统疾病以及肿瘤进展中发挥作用[1][2] 。

种属：Human

蛋白编号：P33527 (V1248-V1531)

基因 ID：4363

同用名：ABC 29; ABC29; ABCC 1; ABCC; Abcc1; ATP binding cassette sub family C CFTR/MRP; member 1; ATP binding cassette sub-family C member 1; ATP binding cassette subfamily C member 1; ATP binding cassette transporter variant ABCC1delta ex13; ATP binding cassette transporter variant ABCC1delta ex13&14; ATP binding cassette transporter variant ABCC1delta ex25; ATP binding cassette transporter variant ABCC1delta ex25&26; ATP binding cassette, sub-family C CFTR/MRP; , member 1; ATP-binding cassette sub-family C member 1; DKFZp686N04233; DKFZp781G125; GS X; GSX; Leukotriene C4; transporter; LTC4 transporter; MRP 1; MRP; MRP1; MRP1_HUMAN; Multidrug resistance associated protein 1; Multidrug resistance protein; Multidrug resistance-associated protein 1; Multiple drug resistance associated protein; Multiple drug resistance protein 1

详情参考：https://www.medchemexpress.cn/recombinant-proteins/abcc1-protein-human-his.html

参考文献：

[1]. Cole SPC, et, al. Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter. J Biol Chem. 2014 Nov 7;289(45):30880-8.
[2]. Munoz M, et, al. Role of the MRP1/ABCC1 multidrug transporter protein in cancer. IUBMB Life. 2007 Dec;59(12):752-7.