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Leptin 蛋白

品牌：MedChemExpress (MCE)

货号：HY-P7232

纯度：Greater than 95% as determined by reducing SDS-PAGE.

运输条件：美国大陆的室温；其他地方可能有所不同。

产品活性：Leptin 蛋白, Human是脂肪细胞分泌的一种激素，通过抑制摄食和增加产热来帮助调节能量平衡。

生物活性：使用人瘦素 R 转染的 BaF3 小鼠 proB 细胞通过趋化性生物测定法测定的 ED50 > 5.0 × 10⁵ IU/mg。

研究背景：传感器（脂肪细胞产生的瘦素）监测脂肪组织块的大小。下丘脑中心通过瘦素受体（LRb）接收并整合瘦素信号的强度。效应系统（包括交感神经系统）控制着能量平衡的两个主要决定因素——能量摄入和能量消耗[1]。瘦素基因的隐性突变与小鼠和人类的严重肥胖有关，为肥胖奠定了遗传基础。瘦素在血液中循环并作用于大脑以调节食物摄入和能量消耗。当脂肪量下降时，血浆瘦素水平下降，刺激食欲并抑制能量消耗，直到脂肪量恢复。当脂肪量增加时，瘦素水平就会增加，抑制食欲直到体重减轻。该系统维持脂肪组织质量的稳态控制[2]。

种属：Human

蛋白编号：P41159 (V22-C167)

基因 ID：3952

同用名：rHuLeptin; Obesity protein; OB

详情参考：https://www.medchemexpress.cn/recombinant-proteins/leptin-protein-human.html

参考文献：

[1]. A sensor (leptin production by adipose cells) monitors the size of the adipose tissue mass. Hypothalamic centers receive and integrate the intensity of the leptin signal through leptin receptors (LRb). Effector systems, including the sympathetic nervous system, control the two main determinants of energy balance-energy intake and energy expenditure[1]. Recessive mutations in the leptingene are associated with massive obesity in mice and humans, establishing a genetic basis for obesity. Leptin circulates in blood and acts on the brain to regulate food intake and energy expenditure. When fat mass falls, plasma leptin levels fall, stimulating appetite and suppressing energy expenditure until fat mass is restored. When fat mass increases, leptin levels increase, suppressing appetite until weight is lost. This system maintains homeostatic control of adipose tissue mass[2].
[2]. Friedman JM, et al. Leptin and the regulation of body weigh. Keio J Med. 2011;60(1):1-9.