IR拮抗剂多肽S961，1083433-49-1，杭州固拓生物多肽物美价廉 新品

Product Name：S961

Synonyms：IR拮抗剂多肽S961

CAS No.：1083433-49-1

Catalog No.：GT-XL0131

Brand：Go Top peptide（杭州固拓）

Description：S961是一种高亲和力、选择性胰岛素受体（IR）拮抗剂，其特异性结合IR的胞外域（ECD），亲和力与胰岛素相当（Kd≈0.1 nM），通过"空间占位"阻止胰岛素与IR结合，可诱导IR二聚化但不能激活胞内激酶域（无法触发自磷酸化），阻断下游PI3K/Akt和MAPK信号通路，对IGF-1R亲和力极低，特异性高。

S961 is a high-affinity, selective insulin receptor (IR) antagonist that specifically binds to the extracellular domain (ECD) of the IR, with an affinity comparable to insulin (Kd ≈ 0.1 nM). It blocks insulin from binding to the IR through a 'steric hindrance' mechanism, can induce IR dimerization but cannot activate the intracellular kinase domain (thus failing to trigger autophosphorylation), and blocks downstream PI3K/Akt and MAPK signaling pathways. It has extremely low affinity for IGF-1R, making it highly specific.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H2O/DMSO

Vacuum-packedwith aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

Sequence(1-letter code)	GSLDESFYDWFERQLGGGSGGSSLEEEWAQIQCEVWGRGCPSY(Disulfidebridge:Cys33-Cys40)
Sequence(3-letter code)	H-Gly-Ser-Leu-Asp-Glu-Ser-Phe-Tyr-Asp-Trp-Phe-Glu-Arg-Gln-Leu-Gly-Gly-Gly-Ser-Gly-Gly-Ser-Ser-Leu-Glu-Glu-Glu-Trp-Ala-Gln-Ile-Gln-Cys-Glu-Val-Trp-Gly-Arg-Gly-Cys-Pro-Ser-Tyr-OH(Disulfidebridge:Cys33-Cys40)
Peptide Structure
Molecular Formula	C211H295N55O71S2
Molecular Weight	4802.11

申明：产品仅供科研使用，不得用于人体。

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