4-溴-3-氟甲苯 4-Bromo-3-fluorotoluene

4-溴-3-氟甲苯

英文名称：4-Bromo-3-fluorotoluene，又名3-氟-4-溴甲苯，是一种分子式为C7H6BrF的有机化合物，CAS号为452-74-4，分子量189.02500。常温下为无色至淡黄色液体，密度1.494 g/mL（25℃），沸点95℃（50mmHg），闪点95℉，折射率n20/D 1.53

具体用途

该化合物作为有机合成中间体，通过重氮化溴代、Schiemann反应等步骤参与药物合成路径，最终用于生产曲格列汀这类糖尿病治疗药物。其合成路线涉及高温重氮化工艺，可提升生产效率并降低能耗。 ‌

物理性质

4-溴-3-氟甲苯为无色透明液体，常温下具有刺激性气味，沸点95℃（50mmHg），密度1.494g/mL（25℃），纯度通常≥98%。

4-Bromo-3-fluorotoluene

English Name: 4-Bromo-3-fluorotoluene, also known as 3-Fluoro-4-bromotoluene, is an organic compound with the molecular formula C₇H₆BrF. Its CAS number is 452-74-4, and its molecular weight is 189.02500. At room temperature, it appears as a colorless to pale yellow liquid, with a density of 1.494 g/mL (at 25°C), a boiling point of 95°C (at 50 mmHg), a flash point of 95°F, and a refractive index of n20/D 1.53.

Specific Applications

This compound serves as an organic synthesis intermediate. It participates in pharmaceutical synthesis pathways through steps such as diazotization bromination and the Schiemann reaction, ultimately used in the production of antidiabetic drugs like Trelegliptin. The synthetic route involves a high-temperature diazotization process, which enhances production efficiency and reduces energy consumption.

Physical Properties

4-Bromo-3-fluorotoluene is a colorless, transparent liquid with a pungent odor at room temperature. It has a boiling point of 95°C (at 50 mmHg), a density of 1.494 g/mL (at 25°C), and a purity typically ≥98%.