抑制剂多肽cyclo(CLLFVY)/1446322-73-1/cyclo(CLLFVY)

Product Name：cyclo(CLLFVY)

CAS No.：1446322-73-1

Synonyms：抑制剂多肽cyclo(CLLFVY)

Catalog No.：220P241

Brand：Typeptide Biotech（肽研生物）

Description：cyclo(CLLFVY) 是缺氧诱导因子-1 (HIF-1) 的抑制剂多肽，是由6个氨基酸组成的环状多肽，IC50 为 19 μM (在 U2OS 中) 和 16 μM (在 MCF-7 中)。cyclo(CLLFVY) 与 HIF-1α 的 PAS-B 结构域结合，抑制 HIF-1 二聚化和转录活性。cyclo(CLLFVY) 下调缺氧反应基因 (如 VEGF 和 CAIX) 的表达，对 HIF-1 相关癌症表现出抗肿瘤作用。

Cyclo (CLLFVY) is an inhibitor peptide of hypoxia inducible factor-1 (HIF-1), which is a cyclic peptide composed of 6 amino acids with IC50 values of 19 μ M (in U2OS) and 16 μ M (in MCF-7). Cyclo (CLLFVY) binds to the PAS-B domain of HIF-1 α, inhibiting HIF-1 dimerization and transcriptional activity. Cyclo (CLLFVY) downregulates the expression of hypoxia responsive genes such as VEGF and CAIX, exhibiting anti-tumor effects on HIF-1 related cancers.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

订购联系方式：

南京肽研生物生物科技有限公司

手机号：19961912513(微信同号)

QQ: 2178255659

邮箱：sales@typeptide.com

联系人：顾经理

申明：本产品仅供科研使用，不得用于人体。