人IL-6Rα / CD126蛋白, His Tag (MALS verified)

Human IL-6 R alpha / CD126 Protein, His Tag (MALS verified)

分子别名（Synonym）

IL6R,CD126,IL-6R-1,IL-6RA,IL6RA,IL-6R-alpha,IL6RQ,gp80

表达区间及表达系统（Source）

Human IL-6 R alpha, His Tag (ILR-H4223) is expressed from human 293 cells (HEK293). It contains AA Leu 20 - Pro 365 (Accession # NP_000556.1).

Predicted N-terminus: Leu 20

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 39.4 kDa. The protein migrates as 55-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method / rFC method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景介绍

白细胞介素6受体（IL6R）又称CD126（分化簇126），是一种强效多效性细胞因子，可调节多种组织的细胞生长与分化，尤其以其在免疫应答和急性期反应中的作用而闻名。IL6R是由白细胞介素6受体亚基（IL6R）与白细胞介素6信号转导糖蛋白130组成的蛋白质复合体。IL6R同样指编码该亚基的人类基因。研究已报道存在编码不同亚型的可变剪接转录本。IL6R亚基亦为多种其他细胞因子所共用。其可溶性形式源自膜结合型IL6Rα的蛋白水解切割，通过使IL6配体能够接触信号转导蛋白gp130而发挥激动作用。IL6与IL6R的生成失调参与多种炎症性疾病及恶性肿瘤（如多发性骨髓瘤、类风湿关节炎、骨质疏松症）的发病机制。据报道，人源化抗IL6R单克隆抗体是适用于IL6驱动性疾病治疗策略的一种前景广阔的制剂。白细胞介素6受体已被证实可与白细胞介素6及睫状神经营养因子发生相互作用。