人Prolactin R / PRLR蛋白, His Tag

Human Prolactin R / PRLR Protein, His Tag

分子别名（Synonym）

Prolactin R, PRLR, PRL-R

表达区间及表达系统（Source）

Human Prolactin R, His Tag (PRR-H52Ha) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Asp 234 (Accession # P16471-1).

Predicted N-terminus: Gln 25

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 26.3 kDa. The protein migrates as 30-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method / rFC method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景介绍

作为一种跨膜受体，催乳素受体（PRL-R）能与催乳素发生相互作用。此外，该受体还可结合生长激素（GH）和人类胎盘催乳素（hPL）并被其激活。临床前研究、流行病学分析及患者组织标本检测均提供了有力证据，表明催乳素受体（PRLR）信号通路在乳腺癌与前列腺癌的发生发展进程中发挥重要作用。更重要的是，研究证实PRLR对妊娠期乳腺的小叶-腺泡成熟过程至关重要——基因敲除PRLR的小鼠模型显示，其乳腺小叶-腺泡结构的发育存在严重缺陷。