人ADAM9蛋白, His Tag

Human ADAM9 Protein, His Tag (active enzyme, HPLC verified)

分子别名（Synonym）

Disintegrin and metalloproteinase domain-containing protein 9 (EC:3.4.24.-) Cellular disintegrin-related protein, Meltrin-gamma, Metalloprotease, disintegrin, cysteine-rich protein 9, Myeloma cell metalloproteinase, ADAM9, KIAA0021, MCMP, MDC9, MLTNG

表达区间及表达系统（Source）

Human ADAM9, His Tag (AD9-H52H7) is expressed from human 293 cells (HEK293). It contains AA Ala 206 - Asp 697 (Accession # Q13443-1).

Predicted N-terminus: Ala 206

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 55.2 kDa. The protein migrates as 55-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method / rFC method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Supplied as 0.2 μm filtered solution in 20 mM Tris, 500 mM NaCl, pH7.5 with glycerol as protectant.

Contact us for customized product form or formulation.

运输（Shipping）

This product is supplied and shipped with dry ice, please inquire the shipping cost.

存储（Storage）

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

The product MUST be stored at -70°C or lower upon receipt;

-70°C for 3 months under sterile conditions.

背景介绍

ADAM9（解整合素-金属蛋白酶9）是一种膜锚定蛋白，通过其去整合素结构域介导细胞黏附，并借助金属蛋白酶结构域介导多种细胞表面蛋白的胞外域脱落，从而参与多种生理功能。ADAM9影响发育进程、炎症反应及退行性疾病。近年来，越来越多证据表明ADAM9在肿瘤生物学中发挥重要作用。在多种癌症类型中均发现ADAM9过表达，且与肿瘤侵袭性增强及不良预后相关。此外，ADAM9通过蛋白水解或非蛋白水解途径促进肿瘤进展、治疗抵抗及癌症转移。因此，全面理解ADAM9的作用机制对于制定抗癌治疗策略至关重要。本文综述了当前对ADAM9在生物学功能、病理生理疾病及各类癌症中作用的认识，并介绍了基于ADAM9相关通路的治疗策略最新进展。