病毒决定结构域七肽/339091-39-3/Amyloid-Forming peptide

Product Name：Amyloid-Forming peptide GNNQQNY  

CAS No.：339091-39-3

Synonyms：病毒决定结构域七肽

Catalog No.：220P219

Brand：Typeptide Biotech（肽研生物）

Description：Amyloid-Forming peptide GNNQQNY是来自酵母蛋白 Sup35 的 N 端朊病毒决定结构域的七肽，序列的疏水性比较强，可形成淀粉样原纤维。其详细的原子低聚结构的可用性使其成为研究聚集早期阶段的良好模型。 GNNQQNY 二聚体形成三个稳定的片状结构。寄存器内并行、寄存器外并行和反并行。对准的平行二聚体接近淀粉样蛋白β-折叠结构，具有很少的肽间氢键，使得疏水相互作用更加重要，并且与反平行折叠相比增加了构象熵。

Amloid Forming peptide GNNQQNY is a heptapeptide derived from the N-terminal prion determining domain of yeast protein Sup35. Its sequence has strong hydrophobicity and can form amyloid fibrils. The availability of its detailed atomic oligomeric structure makes it a good model for studying the early stages of aggregation. GNNQQNY dimer forms three stable sheet-like structures. Parallel within registers, parallel outside registers, and anti parallel. The aligned parallel dimer is close to the amyloid beta fold structure, with few peptide hydrogen bonds, making hydrophobic interactions more important and increasing conformational entropy compared to anti parallel folding.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

订购联系方式：

南京肽研生物生物科技有限公司

手机号：19961912513(微信同号)

QQ: 2178255659

邮箱：sales@typeptide.com

联系人：顾经理

申明：本产品仅供科研使用，不得用于人体。