化合物 CNDAC|T13621L|TargetMol

CNDAC
135598-68-4

￥10600 25mg 起订

上海更新日期：2025-11-17

TargetMol中国（陶术生物）

VIP2年

联系人：邵小姐

手机：15002134094 拨打

邮箱：marketing@targetmol.cn

产品详情:

中文名称：: 化合物 CNDAC

英文名称：: CNDAC

CAS号：: 135598-68-4

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

产品类别：: 抑制剂

货号：: T13621L

Product Introduction

Bioactivity

名称	CNDAC
描述	CNDAC, a nucleoside analog, is a major metabolite of oral drug sapacitabine.
体外活性	CNDAC-induced SSBs can be repaired by the transcription-coupled nucleotide excision repair pathway, whereas lethal DSBs are mainly repaired through homologous recombination and it induces DSBs, which are products of replication, rather than a consequence of induction of apoptosis. Deficiency in two Rad51 paralogs, Rad51D and XRCC3, greatly sensitizes cells to CNDAC. CNDAC shows potent activity against human fibroblasts deficient in ATM or transfected with an empty vector, approximately 30-fold more than cells repleted with full-length ATM cDNA (IC50s: 0.01 μM and 0.3 μM). The Rad51D-null cell line is approximately 50-fold more sensitive to CNDAC (IC50: 0.006 μM) compared to 51D1.3, the Rad51D-repleted line (IC50: 0.32 μM) [1]. CNDAC displays inhibitory activity against HL-60 and THP-1 cells (IC50s: 1.58 μM and 0.84 μM). CNDAC (10?μM) causes a significant drop in cell survival compared to the untreated on days 4, 7, and 14. CNDAC is more effective at reducing the viability and inducing apoptosis than ara-C at equivalent concentrations in the THP-1 cell line [2]. CNDAC causes DNA damage, and DNA-PK and ATR are dispensable for cell survival. CNDAC-induced DNA damage is repaired through the homologous recombination pathway [3].
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
关键字	CNDAC

CNDAC|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(13年)
注册资本	589.8595万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	中间体,天然产物,生物化工,化学试剂,生物技术服务

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