人Cadherin-3 / CDH3蛋白, His Tag

Human Cadherin-3 Protein, His Tag

分子别名（Synonym）

CDH3,CDHP,Cadherin-3,P-cadherin

表达区间及表达系统（Source）

Human Cadherin-3, His Tag (CA3-H52H3) is expressed from human 293 cells (HEK293). It contains AA Asp 108 - Gly 654 (Accession # P22223-1).

Predicted N-terminus: Asp 108

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 61.9 kDa. The protein migrates as 65-70 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method / rFC method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景介绍

钙黏蛋白-3（亦称P-钙黏蛋白）是一种经典的细胞间黏附分子，在多种正常组织中发挥稳态维持功能。在人体中，钙黏蛋白-3仅见于少数器官表达，但其过表达与乳腺癌、肺癌及胰腺癌等实体瘤的不良预后密切相关。