150238-87-2；释放抑制肽Proadrenomedullin (1-20) (human);杭州固拓多肽合成

Product Name：Proadrenomedullin (1-20) (human)
Synonyms：肾上腺髓质素N端20肽（人）

CAS No.：150238-87-2

Catalog No.：GT-XL0052

Brand：Go Top peptide（杭州固拓）

Description：Proadrenomedullin (1-20) 是一种由内源性前体蛋白裂解产生的生物活性肽段，具有降压和抑制儿茶酚胺释放的作用。研究表明，它可通过非竞争性抑制烟碱型胆碱能受体，抑制PC12嗜铬细胞瘤细胞中儿茶酚胺的分泌，IC₅₀ 约为 350 nM，因此也被视为一种潜在的降压肽和神经调节剂，用于心血管疾病、神经系统调节、受体机制研究等。Proadrenomedullin (1-20) is a bioactive peptide segment generated by the cleavage of an endogenous precursor protein, with effects of lowering blood pressure and inhibiting catecholamine release. Studies have shown that it can non-competitively inhibit nicotinic cholinergic receptors and suppress catecholamine secretion in PC12 chromaffin tumor cells, with an IC₅₀ of approximately 350 nM. Therefore, it is also considered a potential hypotensive peptide and neuromodulator for applications in cardiovascular diseases, nervous system regulation, and receptor mechanism research.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H2O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

Sequence(1-letter code)	ARLDVASEFRKKWNKWALSR-NH2
Sequence(3-letter code)	H-Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2
Peptide Structure
Molecular Formula	C112H178N36O27
Molecular Weight	2460.83

申明：产品仅供科研使用，不得用于人体。

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