小鼠Cadherin-17 / CDH17蛋白, His Tag

Mouse Cadherin-17 / CDH17 Protein, His Tag (MALS verified)

分子别名（Synonym）

Cadherin-17,CDH17,HPT-1,LI-cadherin

表达区间及表达系统（Source）

Mouse Cadherin-17, His Tag (CA7-M52H5) is expressed from human 293 cells (HEK293). It contains AA Phe 26 - Met 786 (Accession # Q9R100-1).

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 86.3 kDa. The protein migrates as 95-110 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method / rFC method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 150 mM NaCl, pH8.0 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景介绍

钙黏蛋白17（亦称肝肠钙黏蛋白）属于钙依赖性细胞黏附分子——钙黏蛋白家族。体内研究表明，敲除CDH17基因可通过激活caspase-3活性导致胰腺癌肿瘤细胞凋亡。综上可知，CDH17通过调节肿瘤凋亡信号通路成为调控胰腺癌生长的关键致癌分子，针对该靶点可开发新型胰腺癌治疗方法。