食蟹猴IL-31蛋白, His Tag

Cynomolgus IL-31 Protein, His Tag

分子别名（Synonym）

IL-31, IL31, Interleukin-31

表达区间及表达系统（Source）

Cynomolgus IL-31, His Tag (IL1-C5245) is expressed from human 293 cells (HEK293). It contains AA Leu 27 - Thr 163 (Accession # G7PJ78-1).

Predicted N-terminus: His

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 17.3 kDa. The protein migrates as 20-25 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景介绍

IL-31是一种炎症性细胞因子，能协助启动针对病原体的细胞免疫应答。它通过由IL31RA和OSMR组成的IL-31异二聚体受体，激活STAT3信号通路，并可能激活STAT1与STAT5。该细胞因子已被确认为多种慢性炎症性疾病（包括特应性皮炎）的关键致病因子，可能在皮肤免疫中发挥功能。IL-31由多种细胞产生，主要为2型辅助性T细胞（TH2）。IL-31通过免疫细胞和上皮细胞中表达的IL-31RA与抑瘤素M受体β（OSMRβ）构成的受体复合物传递信号，这些信号会激活三条通路：ERK1/2 MAP激酶通路、PI3K/AKT通路以及JAK1/2信号通路。