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重组小鼠PD-L2 (C-Fc)蛋白 | EnkiLife恩玑生命

Recombinant Mouse PD-L2 (C-Fc)
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湖北 更新日期:2026-01-30

武汉恩玑生命科技有限公司

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联系人:Kiki
电话:027-87002838拨打
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邮箱:order@enkilife.cn

产品详情:

中文名称:
重组小鼠PD-L2 (C-Fc)蛋白
英文名称:
Recombinant Mouse PD-L2 (C-Fc)
品牌:
EnkiLife
产地:
中国
保存条件:
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
产品类别:
重组蛋白
是否进口:
用途:
科研
产品名称

Recombinant Mouse PD-L2 (C-Fc)

英文名称

PD-L2/B7-DC/CD273/Programmed cell death ligand 2  

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素

<1 EU/µg as determined by LAL test.

蛋白构建

Recombinant Mouse Programmed Cell Death 1 Ligand 2 is produced by our Mammalian expression system and the target gene encoding Leu20-Arg219 is expressed with a human IgG1 Fc tag at the C-terminus.

Accession

Q9WUL5

表达宿主

Human Cells

种属

Mouse

预测分子量

49.7 KDa

制剂

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

运输方式

The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.

稳定性&储存

Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

复溶

Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

 

分子别名
Programmed cell death 1 ligand 2;Pdcd1lg2;PD-1 ligand 2;PD-L2; PDCD1 ligand 2; B7-DC; CD273;

 

背景介绍
Programmed cell death 1 ligand 2 (PD-L2), also known as butyrophilin B7-DC or PDCD1 ligand 2, belongs to the member of B7 family which can regulate the activation and tolerance of T cells. PD-L2 is one ligand for Programmed cell death 1(PD-1), and the other is PD-L1. These two ligands shares 34% aa sequence identity. Mouse PD-L2 gene encodes a 273 amino acids (aa) protein with a putative 19 aa signal peptide, a 201 aa extracellular region , a 21 aa transmembrane domain and a 32 aa cytoplasmic region. The mouse PD-L2 gene is highly expressed in heart, placenta, pancreas, lung and liver while expressed weakly in spleen, lymph nodes and thymus. Besides, the expression of PD-L2 gene can be induced on dendritic cells grown from peripheral blood mononuclear cells under CSF2 and IL4/interleukin-4 treatment, and up-regulated by IFNG/IFN-gamma stimulation in monocytes. PD-L2 usually functions in a PDCD1-independent manner and is involved in regulating costimulatory signal which is essential for T-cell proliferation and IFNG production. Recent studies demonstrate that the expression of PD-L2 on the tumor cells promotes CD8 T cell–mediated rejection of tumor cells, at both the induction and effector phase of antitumor immunity. Moreover, PD-L2 binds to PD-1 cells and enhances T cell killing in a PD-1–independent mechanism.

 

注意事项

本司产品仅用于科研,不用于临床诊断和治疗

 

Recombinant;Mouse;PD-L2;protein

公司简介

武汉恩玑生命科技有限公司(EnkiLife)是一家深耕生命科学,专注细胞生物学和免疫学科研试剂的研发、生产与销售的生物技术企业,在全球100多个国家和地区开展业务,致力于为科研工作者提供高质量的产品和卓越的客户服务,推动生命科学的发展。 EnkiLife的产品线涵盖细胞系、原代细胞、细胞培养基、血清、细胞检测试剂盒、重组靶点蛋白、细胞因子、重组抗体、ELISA试剂盒、生化试剂盒等,并提供技术服务与定制开发,覆盖了生命科学研究的各大关键领域,包括细胞生物学、癌症、免疫学、神经科学、心血管疾病、干细胞、表观遗传学、内分泌、蛋白质组学、代谢组学等,全方位满足您的实验需求,让您享受科研的乐趣! 公司现已建立四大技术平台: EnCyto?细胞培养及检测平台:拥有细胞系库(500+)、原代细胞库(500+)、基础培养基和完全培养基(1200+) EnkiPro?重组蛋白平台:现货产品2000+,可提供定制化表达服务 EnAb?重组抗体平台:重组兔单抗(3000+),可提供定制化和标记服务 EnKits?试剂盒开发平台:可提供优质的ELISA试剂盒、配套试剂、抗体对、生化试剂盒等相关产品 EnkiLife在生产管理方面引入ISO9001质量管理体系和信息化、自动化的管理工具,拥有高效稳定的交付能力,与全球知名品牌建立了紧密的合作。 EnkiLife始终坚持以技术创新为驱动,以匠心铸就品质,以品质服务客户。 我们期待与更多的全球科研工作者和企业携手合作,共同推动生命科学领域的进步与发展。

成立日期 (2年)
注册资本 271万人民币
员工人数 10-50人
年营业额 ¥ 100万-300万
经营模式 工厂,试剂,定制,服务
主营行业 生化试剂,抗体,细胞培养,癌症研究,细胞生物学

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