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网站主页 重组人IL-15RA&IL-15 Complex (C-Fc)蛋白 重组人IL-15RA&IL-15 Complex (C-Fc)蛋白
  • 重组人IL-15RA&IL-15 Complex (C-Fc)蛋白 | EnkiLife恩玑生命

重组人IL-15RA&IL-15 Complex (C-Fc)蛋白 | EnkiLife恩玑生命

Recombinant Human IL-15RA&IL-15 Complex (C-Fc)
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湖北 更新日期：2025-11-13

武汉恩玑生命科技有限公司

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产品详情:

中文名称：
重组人IL-15RA&IL-15 Complex (C-Fc)蛋白
英文名称：
Recombinant Human IL-15RA&IL-15 Complex (C-Fc)
品牌：
EnkiLife
产地：
中国
保存条件：
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.Reconstituted protein solution can be stored at 2-8°C for 2-7 days.Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
产品类别：
重组蛋白
是否进口：
否
用途：
科研
产品名称

Recombinant Human IL-15RA&IL-15 Complex (C-Fc)
英文名称

IL-15RA&IL-15 Complex/IL-15 R alpha & IL-15 Fusion Protein/IL15RA&IL15  
纯度

Greater than 95% as determined by reducing SDS-PAGE
内毒素

<1 EU/µg as determined by LAL test.
蛋白构建

Recombinant Human Interleukin-15 Receptor Alpha & Interleukin-15 Fusion Protein Complex is produced by our Mammalian expression system and the target gene encoding Ile31-Asp96&Asn49-Ser162 (Asn120Asp) is expressed with a human IgG1 Fc tag at the C-terminus.
Accession

Q13261&P40933
表达宿主

Human Cells
种属

Human
预测分子量

34.4&12.8 KDa
制剂

Lyophilized from a 0.2 μm filtered solution of PBS, 5% Trehalose, pH 7.4.
运输方式

The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
稳定性&储存

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.Reconstituted protein solution can be stored at 2-8°C for 2-7 days.Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶

Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

 

分子别名
IL-15 Receptor alpha & IL-15 Fusion Protein; IL15RA&IL15; IL15RA&IL15 Complex; Interleukin-15; IL-15; IL15

 

背景介绍
IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL-15RA with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each others activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs. The enhanced activity of the IL-15N72D:IL-15RαSu/Fc complex is likely the result of the increased binding activity of IL-15N72D to IL-15Rβγ c , optimized cytokine trans-presentation by the IL-15RαSu domain, the dimeric nature of the cytokine domain and its increased in vivo half-life compared to IL-15. These findings indicate that this IL-15 superagonist complex could serve as a superior immunostimulatory therapeutic agent.

 

注意事项

本司产品仅用于科研，不用于临床诊断和治疗

 

Recombinant;Human;IL-15RA&IL-15 Complex;protein

公司简介

武汉恩玑生命科技有限公司（EnkiLife）是一家深耕生命科学，专注细胞生物学和免疫学科研试剂的研发、生产与销售的生物技术企业，在全球100多个国家和地区开展业务，致力于为科研工作者提供高质量的产品和卓越的客户服务，推动生命科学的发展。 EnkiLife的产品线涵盖细胞系、原代细胞、细胞培养基、血清、细胞检测试剂盒、重组靶点蛋白、细胞因子、重组抗体、ELISA试剂盒、生化试剂盒等，并提供技术服务与定制开发，覆盖了生命科学研究的各大关键领域，包括细胞生物学、癌症、免疫学、神经科学、心血管疾病、干细胞、表观遗传学、内分泌、蛋白质组学、代谢组学等，全方位满足您的实验需求，让您享受科研的乐趣！ 公司现已建立四大技术平台： EnCyto?细胞培养及检测平台：拥有细胞系库（500+）、原代细胞库（500+）、基础培养基和完全培养基（1200+） EnkiPro?重组蛋白平台：现货产品2000+，可提供定制化表达服务 EnAb?重组抗体平台：重组兔单抗（3000+），可提供定制化和标记服务 EnKits?试剂盒开发平台：可提供优质的ELISA试剂盒、配套试剂、抗体对、生化试剂盒等相关产品 EnkiLife在生产管理方面引入ISO9001质量管理体系和信息化、自动化的管理工具，拥有高效稳定的交付能力，与全球知名品牌建立了紧密的合作。 EnkiLife始终坚持以技术创新为驱动，以匠心铸就品质，以品质服务客户。 我们期待与更多的全球科研工作者和企业携手合作，共同推动生命科学领域的进步与发展。

成立日期 (2年)
注册资本 271万人民币
员工人数 10-50人
年营业额 ￥ 100万-300万
经营模式 工厂,试剂,定制,服务
主营行业 生化试剂,抗体,细胞培养,癌症研究,细胞生物学

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