化合物 5-Aza-4'-thio-2'-deoxycytidine|T85478|TargetMol

5-Aza-4'-thio-2'-deoxycytidine
169514-76-5

￥13800 50mg 起订

上海更新日期：2026-05-08

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产品详情:

中文名称：: 化合物 5-Aza-4'-thio-2'-deoxycytidine

英文名称：: 5-Aza-4'-thio-2'-deoxycytidine

CAS号：: 169514-76-5

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

产品类别：: 抑制剂

货号：: T85478

Product Introduction

Bioactivity

名称	5-Aza-4'-thio-2'-deoxycytidine
描述	5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd), a sulfur-containing deoxy-cytidine analog, serves as an orally active inhibitor of DNA methyltransferase I (DNMT1). It exhibits potential antitumor effects and DNA hypomethylating properties [1].
体外活性	5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd; 72 h) effectively inhibits various leukemia lines, including CCRF-CEM (IC 50 =0.2 μM) and KG1a (IC 50 =0.06 μM). This compound also reduces the viability of several carcinoma lines, such as NCI-H23 lung carcinoma (IC 50 =4.5 μM), HCT-116 colon carcinoma (IC 50 =58 μM), and IGROV-1 ovarian carcinoma (IC 50 =36 μM) [1]. It significantly depletes DNMT1 in the NCI-H23, HCT-116, and IGROV-1 cells, as well as in CCRF-CEM and KG1a myeloid leukemia cells across various dosages (0.1-20 μM; 96 h) [1]. Furthermore, at a concentration of 1 μM and an incubation period of 96 h, 5-Aza-4'-thio-2'-deoxycytidine induces CpG demethylation and reactivates the p15 tumor suppressor gene [1]. Western blot analysis confirms that DNMT1 is markedly depleted in NCI-H23, HCT-116, and IGROV-1 cells treated with concentrations of 1, 5, 10, 20 μM for 96 h [1].
体内活性	5-Aza-4'-thio-2'-deoxycytidine administered intraperitoneally at dosages of 6.7 and 10 mg/kg/day over 9 days demonstrates significant antitumor efficacy against NCI-H23 tumor xenografts in young female athymic nu/nu mice [1]. At a reduced dose of 5 mg/kg/day for the same duration, this compound effectively reduces DNMT1 levels in CCRF-CEM tumor mice xenografts [1]. Additionally, a regimen of 1.5 mg/kg given daily for five days, followed by a rest period and repeating for three cycles, achieves modest suppression in the growth of HCT116 colon carcinoma and OVCAR3 ovarian tumor xenografts. However, it exhibits minimal antitumor effects on HL-60 leukemia xenografts [2].
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.

NTX-301|||5-Aza-T-dCyd|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(14年)
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主营行业	中间体,天然产物,生物化工,化学试剂,生物技术服务

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