人IL-31RA蛋白, His Tag

Human IL-31 RA Protein, His Tag (MALS & SPR verified)

分子别名（Synonym）

IL-31 RA, IL-31RA, hGLM-R, CRL3, GPL, ZcytoR17, GLM-R, IL-31R-alpha, Gp130-like receptor

表达区间及表达系统（Source）

Human IL-31 RA, His Tag (ILA-H52H7) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Glu 519 (Accession # Q8NI17-1).

Predicted N-terminus: Ala 20

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 59.0 kDa. The protein migrates as 90-110 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method / rFC method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at: \

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景介绍

白细胞介素-31受体α亚基（IL-31 receptor subunit alpha）是一种由IL31RA基因编码的蛋白质，亦称为IL-31RA、GLM-R、Gp130样受体、CRL3或GPL。该蛋白与抑瘤素M受体（OSMR）共同形成异源二聚体受体，介导IL-31的信号传导。IL-31RA能强烈激活STAT3和STAT5的酪氨酸磷酸化，而对STAT1的激活作用较弱。研究还证实，Jak1不仅能与OSMRβ组成异源复合物，还能在同源受体复合物中与GPL结合并激活。