人BAFFR蛋白, His Tag (MALS verified)

Human BAFFR / TNFRSF13C Protein, His Tag (MALS verified)

分子别名（Synonym）

BAFFR,TNFRSF13C,BROMIX,CD268,CVID4,prolixin,BAFF-R

表达区间及表达系统（Source）

Human BAFFR Protein, His Tag (BAR-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ser 7 - Ala 71 (Accession # Q96RJ3-1).

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 8.6 kDa. The protein migrates as 17-22 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method / rFC method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景介绍

BAFF受体（B细胞活化因子受体，BAFF-R），又称肿瘤坏死因子受体超家族成员13C（TNFRSF13C），是肿瘤坏死因子受体超家族中识别BAFF的膜蛋白。B细胞活化因子（BAFF）在体外能增强B细胞存活能力，是外周B细胞群的重要调节因子。小鼠体内BAFF的过度表达会导致成熟B细胞增生并出现系统性红斑狼疮（SLE）症状。此外，部分SLE患者血清中BAFF水平升高。因此有观点认为，异常升高的BAFF可能通过促进自身反应性B细胞的存活，进而参与自身免疫性疾病的发病机制。