人BCMA蛋白, His Tag

PE-Labeled Human BCMA / TNFRSF17 Protein, His Tag (Site-specific conjugation)

分子别名（Synonym）

TNFRSF17, CD269, BCM, BCMA

表达区间及表达系统（Source）

PE-Labeled Human BCMA, His Tag (BCA-HP2H2) is produced via site-specific conjugation of PE to Human BCMA, His Tag under optimal conditions with a proprietary technology. Human BCMA, His Tag is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 54 (Accession # Q02223-1).

Predicted N-terminus: Met 1

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 9.6 kDa.

偶联（Conjugate）

PE

Excitation Wavelength: 488 nm / 561 nm

Emission Wavelength: 575 nm

应用说明（Application）

Please note that this product is NOT compatible to streptavidin detection system.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, 0.5% BSA, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please protect from light and avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 6 months under sterile conditions after reconstitution.

背景介绍

肿瘤坏死因子受体超家族成员17（TNFRSF17），也称为B细胞成熟蛋白（BCMA）或CD抗原CD269（CD269），是肿瘤坏死因子受体超家族（TNF-receptor superfamily）的一员。该受体包含一个TNFR-Cys重复结构域，并特异性表达于成熟B细胞表面，而在T细胞和单核细胞中不表达。TNFRSF17是TNFSF13B/BLyS/BAFF 和 TNFSF13/APRIL 这两种重要配体的受体，其主要功能在于促进B细胞的存活并参与体液免疫的调节。该受体通过激活NF-κB和JNK信号通路来介导其生物学效应。