人BCMA蛋白, His Tag, premium grade

Human BCMA / TNFRSF17 Protein, His Tag, premium grade

分子别名（Synonym）

TNFRSF17,CD269,BCM,BCMA

表达区间及表达系统（Source）

Human BCMA, His Tag, premium grade (BCA-H522y) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 54 (Accession # Q02223-1).

Predicted N-terminus: Met 1

本产品在严格的质量控制体系下生产，涵盖无菌检测及内毒素检测等全套测试。产品性能经严谨验证，确保其在细胞培养应用及临床前研究阶段其他用途中的兼容性。当您的研究进入临床阶段后，我们还可提供定制化GMP蛋白服务：根据您的具体需求，我们将协同开发符合要求的GMP级产品，同时满足细胞治疗产品制造中原辅材料的使用规范。

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 7.8 kDa. The protein migrates as 12 kDa and 14-18 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 0.01 EU per μg by the LAL method / rFC method.

无菌（Sterility）

Negative

支原体（Mycoplasma）

Negative

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 24 months in lyophilized state;

-70°C for 12 months under sterile conditions after reconstitution.

背景介绍

肿瘤坏死因子受体超家族成员17（TNFRSF17）又称B细胞成熟蛋白（BCMA）、CD抗原CD269，是TNF受体超家族成员。该蛋白包含一个TNFR-Cys重复序列，表达于成熟B细胞中，但在T细胞或单核细胞中不表达。作为TNFSF13B/BLyS/BAFF和TNFSF13/APRIL的受体，TNFRSF17能促进B细胞存活并参与调控体液免疫，同时可激活NF-κB和JNK信号通路。