人CCL27蛋白, His Tag

Human CCL27 Protein, His Tag

分子别名（Synonym）

ALP, CTACK, CTAK, ESKINE, ILC, PESKY, SCYA27

表达区间及表达系统（Source）

Human CCL27 Protein, His Tag (CC7-H5143) is expressed from E. coli cells. It contains AA Phe 25 - Gly 112 (Accession # Q9Y4X3).

Predicted N-terminus: Met

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 12.2 kDa. The protein migrates as 11 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method / rFC method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, 0.2 M Arginine, pH7.3 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景介绍

该基因位于9号染色体短臂（p-arm），是与多个CC趋化因子基因聚集于此的基因簇成员之一。细胞因子作为参与免疫调节与炎症反应的分泌蛋白家族，其CC亚型以两个相邻半胱氨酸为结构特征。本基因编码的蛋白质对皮肤归巢记忆T淋巴细胞具有趋化活性，该细胞因子还介导淋巴细胞向皮肤组织的定向迁移。它能特异性结合趋化因子受体CCR10（chemokine receptor 10）。基于小鼠同源蛋白的研究表明，此类蛋白-受体相互作用在T细胞介导的皮肤炎症中发挥枢纽作用。