人CCL11蛋白, His Tag

Human CCL11 Protein, His Tag

分子别名（Synonym）

SCYA11

表达区间及表达系统（Source）

Human CCL11 Protein, His Tag (CC1-H51H3) is expressed from E. coli cells. It contains AA Gly 24 - Pro 97 (Accession # P51671).

Predicted N-terminus: Met

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 10.1 kDa. The protein migrates as 12 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method / rFC method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, 250mM NaCl, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景介绍

该抗菌基因位于17号染色体长臂上，是聚集于此的多个趋化因子基因之一。趋化因子作为超家族分泌蛋白，参与免疫调节及炎症反应过程。该超家族根据成熟肽链N端半胱氨酸的排列方式分为四个亚家族。本基因编码的趋化因子属于CC亚家族成员，对嗜酸性粒细胞具有趋化活性（但不包括单核细胞及中性粒细胞）。这种嗜酸性粒细胞特异性趋化因子被认为参与特应性皮炎、过敏性鼻炎、哮喘及寄生虫病等嗜酸性粒细胞相关性炎症疾病。