人ProS1蛋白, His Tag

Human ProS1 Protein, His Tag

分子别名（Synonym）

PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6

表达区间及表达系统（Source）

Human ProS1 Protein, His Tag (PR1-H52H3) is expressed from human 293 cells (HEK293). It contains AA Val 284 - Ser 676 (Accession # P07225).

Predicted N-terminus: Val 284

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 45.6 kDa. The protein migrates as 53-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method / rFC method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景介绍

该基因属于白细胞免疫球蛋白样受体（LIR）家族成员，位于19号染色体q13.4区域的基因簇中。其编码蛋白归属于LIR受体的B类亚家族，这类受体包含2-4个胞外免疫球蛋白结构域、1个跨膜结构域及2-4个胞质内基于酪氨酸的免疫受体抑制基序（ITIMs）。该受体在免疫细胞表面表达，通过结合抗原呈递细胞上的MHC I类分子，传递抑制性信号以阻断免疫反应的激活。其功能在于调控炎症反应和细胞毒性作用，从而精确引导免疫应答并限制自身反应性。目前已发现该基因存在编码不同亚型的多种转录变异体。