化合物 Taspoglutide|T13091|TargetMol

Taspoglutide
275371-94-3

￥2910 25mg 起订

上海更新日期：2025-11-17

TargetMol中国（陶术生物）

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产品详情:

中文名称：: 化合物 Taspoglutide

英文名称：: Taspoglutide

CAS号：: 275371-94-3

品牌：: TargetMol

产地：: 美国

保存条件：: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

产品类别：: 抑制剂

货号：: T13091

Product Introduction

Bioactivity

名称	Taspoglutide
描述	Taspoglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist(EC50 value of 0.06 nM),and for treatment of type 2 diabetes
体外活性	Taspoglutide (R1583/BIM51077) with 93% homology with the native polypeptide, and is a long acting 10% formulation of (Aib8-35) human GLP-1 (7-36 amides) . It activates the GLP-1 receptor. Taspoglutide has comparable affinity (affinity constant 1.1±0.2 nM) to the natural ligand affinity constant 1.5±0.3 nM for the hGLP-1 receptor and exhibits comparable potency in stimulating cAMP production[2].
体内活性	The rate of glucose-induced insulin secretion from isolated enhanced by Taspoglutide, cultured rat islets and the perfused ZDF rat pancreas. Taspoglutide showed dose-dependent enhancement of glucose-dependent insulin release in Sprague-Dawley rats and diabetic db/db mice, thereby reducing blood glucose in the type 2 diabetic db/db mouse model[3]. Acute treatment with taspoglutide reduces glucose excursion and increased insulin response during oGTT. In chronically treated rats, glucose excursion and levels of GIP, PYY and triglycerides during oGTT on day 21 are significantly reduced[4]. Hepatic triglyceride levels are significantly reduced in livers from taspoglutide-treated. Taspoglutide does not reduce plaque area or lipid content in the aortic arch or abdominal aorta, and no significant change in aortic macrophage accumulation is detected after taspoglutide or metformin mice[5].
存储条件	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 28 mg/mL (8.38 mM), Sonication is recommended.
关键字	Taspoglutide \| R-1583 \| R 1583 \| ITM-077 \| ITM 077 \| GLP-1 \| BIM-51077 \| BIM 51077

R1583|||ITM077|||BIM51077|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

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