beta IV Tubulin抗体;beta IV Tubulin Antibody—艾普蒂 新品

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     Western blot analysis of beta IV Tubulin in mouse brain lysates using beta IV Tubulin antibody.    

  
  

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     Western blot analysis of beta IV Tubulin in K562, rat Brain, C6, Hela lysates using beta IV Tubulin antibody.    

  
  

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     Immunocytochemistry analysis of beta IV Tubulin(green) in Hela using beta IV Tubulin antibody,and DAPI(blue)    

  
  

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     Immunohistochemistry analysis of paraffin-embedded Human brain using beta IV Tubulin antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.    

  
  

Beta IV tubulin, a member of the β-tubulin family, is a structural protein critical for forming microtubules—dynamic cytoskeletal components essential for cell division, intracellular transport, and maintaining cell shape. Unlike other β-tubulin isoforms (e.g., βIII-tubulin in neurons), βIV-tubulin is specifically enriched in ciliated cells and neuronal axons, particularly in specialized structures like the axonemes of motile cilia and flagella. Its unique C-terminal sequence distinguishes it from other isoforms, enabling selective antibody targeting.

Antibodies against βIV-tubulin are widely used in research to identify and study ciliated cell populations, neuronal projections, and cellular differentiation. In neuroscience, they help map axonal pathways or visualize cilia in ependymal cells and photoreceptors. In disease research, these antibodies aid in exploring ciliopathies (e.g., primary ciliary dyskinesia), neurodevelopmental disorders, and cancers where cilia dysfunction or microtubule dynamics are implicated. Common techniques include immunofluorescence, immunohistochemistry, and Western blotting. Specificity validation via knockout controls is crucial, as cross-reactivity with other β-tubulin isoforms can occur. Overall, βIV-tubulin antibodies serve as vital tools for understanding cellular architecture and disease mechanisms linked to microtubule-related pathways.