beta III Tubulin抗体;beta III Tubulin Antibody—艾普蒂

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     Western blot analysis of beta III Tubulin in mouse brain lysates using beta III Tubulin antibody.    

  
  

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     Western blot analysis of beta III Tubulin in rat Brain, Hela lysates using beta III Tubulin antibody.    

  
  

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     Immunocytochemistry analysis of beta III Tubulin (green) in Hela using beta III Tubulin antibody,and DAPI(blue).    

  
  

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     Immunohistochemistry analysis of paraffin-embedded Human Cholangiocarcinoma using beta III Tubulin antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.    

  
  

Beta III Tubulin (βIII-Tubulin), also known as TUBB3. is a member of the β-tubulin protein family and a key component of microtubules, which are critical for cellular structure, intracellular transport, and cell division. This specific isoform is predominantly expressed in neurons, where it plays essential roles in neurogenesis, axon guidance, and maintaining neuronal morphology. Its neuron-specific expression has made it a widely recognized biomarker for identifying neurons, monitoring neuronal differentiation, and studying nervous system development.

Antibodies targeting beta III Tubulin are extensively used in neuroscience research and diagnostics. They enable the visualization of neuronal populations in tissues through techniques like immunohistochemistry (IHC) and immunofluorescence (IF), and detection in protein assays such as Western blot. Beyond normal physiology, beta III Tubulin is implicated in pathological conditions. Its overexpression has been observed in aggressive cancers, including neuroblastomas, glioblastomas, and certain carcinomas, where it may correlate with drug resistance and poor prognosis. Consequently, beta III Tubulin antibodies also serve as tools in cancer research to study tumor progression or assess neural components within tumors.

Additionally, these antibodies contribute to research on neurodegenerative diseases (e.g., Alzheimer’s) and neurodevelopmental disorders. However, cross-reactivity with other β-tubulin isoforms in non-neuronal tissues can occur, necessitating careful validation for experimental specificity. Overall, beta III Tubulin antibodies remain indispensable in both basic and translational biomedical studies.