Axin 2抗体;Axin 2 Antibody—艾普蒂

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     Western blot analysis of Axin 2 in K562, C6, 3T3, Hela lysates using Axin 2 antibody.    

  
  

Axin2 (Axis Inhibition Protein 2) is a key regulatory component of the Wnt/β-catenin signaling pathway, a critical pathway involved in embryonic development, tissue homeostasis, and cancer progression. The Axin2 antibody is a widely used tool to detect and study the expression, localization, and function of the Axin2 protein. Axin2 acts as a scaffold protein in the β-catenin destruction complex, promoting the phosphorylation and degradation of β-catenin to suppress Wnt signaling. Its expression is tightly regulated by Wnt activity, making it a reliable transcriptional target and feedback inhibitor of the pathway.

In research, Axin2 antibodies are employed to investigate Wnt pathway activation in various contexts, including stem cell biology, tissue regeneration, and cancer. Elevated Axin2 levels are often associated with Wnt-driven cancers (e.g., colorectal, hepatocellular carcinoma) and developmental disorders. The antibody is commonly used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess Axin2 protein levels in cell lines, organoids, and tissue samples.

Additionally, Axin2 antibodies have therapeutic implications, as targeting Axin2 or its interactors may modulate Wnt signaling. Recent studies also explore its role in regulating cellular responses to DNA damage and metabolic stress. Despite its utility, antibody specificity and cross-reactivity with other Axin family members (e.g., Axin1) require careful validation in experimental models. Overall, Axin2 antibodies remain vital for dissecting Wnt pathway dynamics and developing related biomarkers or therapies.