APPBP1抗体;APPBP1 Antibody—艾普蒂 新品

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     Western blot analysis of APPBP1 in SKOV-3 lysates using APPBP1 antibody.    

  
  

The APPBP1 (Amyloid Beta Precursor Protein Binding Protein 1) antibody is a tool used to detect and study the APPBP1 protein, also known as BAZ1A (Bromodomain Adjacent to Zinc Finger Domain 1A). APPBP1 is a member of the bromodomain-containing protein family, involved in chromatin remodeling and transcriptional regulation. It interacts with the amyloid precursor protein (APP), a key player in Alzheimer’s disease pathogenesis, suggesting a potential role in neurodegenerative pathways. Additionally, APPBP1 is a component of the NSL (Non-Specific Lethal) histone acetyltransferase complex, regulating histone H4 acetylation and gene expression.

Antibodies targeting APPBP1 are widely used in research to investigate its expression, localization, and interactions in cellular models, often via techniques like Western blotting, immunofluorescence, or immunohistochemistry. These studies aim to elucidate its functions in chromatin dynamics, neural development, and disease mechanisms, including cancer and neurological disorders. Researchers also explore APPBP1's involvement in cell cycle regulation and DNA repair processes.

When using APPBP1 antibodies, specificity validation is critical, as cross-reactivity with homologous proteins (e.g., other bromodomain family members) may occur. Applications typically require verification through knockout controls or orthogonal methods like mass spectrometry. Commercial antibodies vary in performance across species and experimental setups, necessitating optimization for consistent results.