AP3M1抗体;AP3M1 Antibody—艾普蒂

The AP3M1 antibody targets the Adaptor Related Protein Complex 3 Subunit Mu 1 (AP3M1), a key component of the AP-3 complex involved in intracellular vesicle trafficking and protein sorting. The AP-3 complex mediates cargo transport from endosomes to lysosomes and lysosome-related organelles, such as melanosomes and platelet dense granules. AP3M1. the μ subunit, plays a critical role in recognizing tyrosine-based sorting signals on cargo proteins. Mutations in the AP3M1 gene are linked to Hermansky-Pudlak syndrome type 10 (HPS10), a rare genetic disorder characterized by oculocutaneous albinism, bleeding disorders, and immune dysfunction due to defects in lysosome-related organelle biogenesis. AP3M1 antibodies are widely used in research to study protein trafficking mechanisms, lysosomal function, and cellular organelle dynamics. They enable detection of AP3M1 expression via techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding investigations into its role in neurological processes, immune regulation, and cancer biology. Validated antibodies help identify AP3M1 dysregulation in pathological contexts, offering insights into therapeutic targeting. Specificity is confirmed using knockout controls or siRNA knockdown, ensuring reliable experimental outcomes. These tools are essential for advancing understanding of AP3M1's contributions to cellular homeostasis and disease.