AP2 alpha抗体;AP2 alpha Antibody—艾普蒂 新品

The AP-2 alpha antibody targets transcription factor AP-2 alpha (TFAP2A), a member of the AP-2 family of DNA-binding proteins critical for regulating gene expression during embryogenesis and cellular differentiation. TFAP2A contains a helix-span-helix dimerization domain and a basic region for DNA interaction, enabling it to bind specific promoter/enhancer sequences (e.g., GC-rich motifs) to activate or repress target genes. It plays essential roles in neural crest cell development, craniofacial morphogenesis, and epidermal tissue formation. Dysregulation of TFAP2A is implicated in cancers, including breast cancer, melanoma, and neuroblastoma, where it may act as a tumor suppressor or oncogene depending on context. AP-2 alpha antibodies are widely used in research to study its expression patterns, subcellular localization, and interaction partners via techniques like Western blotting, immunohistochemistry (IHC), and chromatin immunoprecipitation (ChIP). These antibodies help elucidate TFAP2A's role in developmental disorders (e.g., branchiooculofacial syndrome) and cancer progression, aiding in biomarker discovery and therapeutic targeting. Commercial AP-2 alpha antibodies are typically validated for specificity using knockout controls or siRNA-mediated knockdown.