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  • HP1 gamma抗体;HP1 gamma Antibody—艾普蒂
  • HP1 gamma抗体;HP1 gamma Antibody—艾普蒂
  • HP1 gamma抗体;HP1 gamma Antibody—艾普蒂

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HP1 gamma抗体;HP1 gamma Antibody—艾普蒂 新品

Mouse Monoclonal HP1gamma Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-06-03

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
HP1 gamma抗体
英文名称：
Mouse Monoclonal HP1gamma Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 9183 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
HP1 gamma

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesCBX3; Chromobox protein homolog 3; HECH; Heterochromatin protein 1 homolog gamma; HP1 gamma; Modifier 2 protein
Entrez GeneID11335
clone9G7
WB Predicted band sizeCalculated MW: 21 kDa; Observed MW: 24 kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenPurified recombinant protein expressed in E.coli.
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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       Western blot analysis of HP1 gamma in Hela lysates , 3T3 lysates , PC-12 lysates using HP1 gamma antibody    


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       Western blot analysis of HP1 gamma in MCF-7, HepG2, Raw264.7, Hela lysates using HP1 gamma antibody.    


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       Immunohistochemistry analysis of paraffin-embedded Human Colon Carcinoma Tissue using HP1 gamma antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.    


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       Immunohistochemical analysis of paraffin-embedded Human tonsils using HP1 gamma antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.    


           

参考文献

以下是3篇与HP1γ抗体相关的代表性文献摘要(基于公开研究整理，非实时数据库检索)：

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1. **文献名称**: *HP1γ mediates genome stability and cancer metastasis through transcriptional silencing*

**作者**: Lomberk G. et al.

**摘要**: 研究揭示了HP1γ通过结合组蛋白H3K9me3标记，调控染色质压缩和基因沉默，从而维持基因组稳定性。利用HP1γ抗体进行ChIP-seq分析，发现其靶基因参与抑制肿瘤转移通路，为癌症治疗提供新靶点。

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2. **文献名称**: *Heterochromatin Protein 1γ promotes DNA repair by stabilizing chromatin condensation*

**作者**: Eissenberg J.C. et al.

**摘要**: 通过免疫荧光和共聚焦显微镜(使用HP1γ抗体)，证实HP1γ在DNA损伤修复中通过维持异染色质结构完整性，促进同源重组修复，揭示了其在细胞周期检查点中的关键作用。

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3. **文献名称**: *Dynamic interaction of HP1γ with LINE-1 retrotransposons during cellular differentiation*

**作者**: Festenstein R. et al.

**摘要**: 研究利用HP1γ抗体的免疫共沉淀(Co-IP)技术，发现HP1γ通过与LINE-1转座子互作调控干细胞分化，其缺失导致转座子异常激活并阻碍分化进程，强调了表观遗传调控在发育中的重要性。

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如需具体实验应用，可优先选择近年文献中涉及抗体验证方法(如Western blot、IF的种属及货号)的研究。

       

背景信息

The HP1γ (Heterochromatin Protein 1 gamma) antibody is a crucial tool for studying epigenetic regulation and chromatin organization. HP1γ, also known as CBX3. is a member of the HP1 protein family, which plays a key role in maintaining heterochromatin structure and gene silencing. It binds to trimethylated lysine 9 on histone H3 (H3K9me3), a post-translational modification associated with transcriptionally repressive chromatin. HP1 proteins facilitate chromatin compaction by bridging histone modifications and recruiting effector molecules involved in gene repression, DNA repair, and telomere stability.

HP1γ is ubiquitously expressed and implicated in diverse cellular processes, including cell cycle regulation, differentiation, and viral defense. Unlike its isoforms HP1α and HP1β, HP1γ shows dynamic nucleocytoplasmic shuttling and may regulate mRNA processing. Dysregulation of HP1γ is linked to cancer progression, developmental disorders, and aging.

The HP1γ antibody is widely used in techniques like chromatin immunoprecipitation (ChIP), Western blotting, and immunofluorescence to map its genomic localization, assess expression levels, and study its interaction partners. Its specificity for HP1γ (distinct from other HP1 isoforms) makes it valuable for dissecting isoform-specific functions. Researchers rely on this antibody to explore HP1γ's role in epigenetic inheritance, chromatin dynamics, and disease mechanisms, underscoring its importance in molecular and cellular biology studies.

       
HP1 gamma抗体;HP1 gamma;HP1 gamma Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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