Peroxiredoxin 1抗体;Peroxiredoxin 1 Antibody—艾普蒂 新品

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     Western blot analysis of Prdx 1 in T47D, 3T3, COS7, C6 and Hela lysates using Prdx 1 antibody.    

  
  

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     Western blot analysis of Peroxiredoxin 1 in MCF-7, rat Kidney , mouse Brain lysates using Peroxiredoxin 1 antibody.    

  
  

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     Western blot analysis of Peroxiredoxin 1 in urkat, CHO-K1, C6, Hela lysates using Peroxiredoxin 1 antibody    

  
  

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     Immunofluorescence analysis of Peroxiredoxin 1 in Hela using Peroxiredoxin 1 antibody(left) ,and DAPI (blue).    

  
  

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     Immunohistochemistry analysis of paraffin-embedded Human tonsil tissue using Peroxiredoxin 1/PAG antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.    

  
  

Peroxiredoxin 1 (Prx1) is a ubiquitously expressed antioxidant enzyme belonging to the peroxiredoxin family, which plays a critical role in regulating cellular redox homeostasis by scavenging reactive oxygen species (ROS), particularly hydrogen peroxide. Prx1 is involved in diverse cellular processes, including cell proliferation, apoptosis, and inflammation, and its dysregulation has been linked to cancer, neurodegenerative diseases, and aging. Structurally, Prx1 contains a conserved peroxidatic cysteine residue that undergoes oxidation during catalysis, followed by recycling via thioredoxin-dependent reduction.

Antibodies targeting Prx1 are essential tools for studying its expression, localization, and functional roles in biological systems. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect Prx1 levels in tissues or cultured cells. Given its relevance in oxidative stress responses, Prx1 antibodies are particularly valuable in research on diseases associated with ROS imbalance. For example, elevated Prx1 expression has been observed in various cancers, correlating with tumor progression and chemoresistance, while reduced levels are implicated in neurodegenerative conditions.

When selecting a Prx1 antibody, specificity validation (e.g., knockout controls) is crucial due to potential cross-reactivity with other peroxiredoxin family members. Commercial antibodies are typically raised in rabbits or mice, with monoclonal and polyclonal options available. Researchers should optimize experimental conditions based on sample type and application to ensure reliable results. Overall, Prx1 antibodies serve as indispensable reagents for exploring oxidative stress mechanisms and developing therapeutic strategies targeting redox signaling pathways.