Rabbit IgG Fc抗体;Rabbit IgG Fc Antibody—艾普蒂 新品

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     Western blot analysis of Reduced Rabbit IgG, H+L using Rabbit IgG Fc antibody.    

  
  

Rabbit IgG Fc antibodies are immunoglobulins generated against the crystallizable fragment (Fc) region of rabbit immunoglobulin G (IgG). The Fc region, located in the heavy chain constant domain, mediates effector functions such as binding to Fc gamma receptors (FcγRs) on immune cells (e.g., macrophages, neutrophils) and complement proteins, thereby triggering immune responses like phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), or complement-dependent cytotoxicity (CDC).

Rabbit-derived antibodies are widely used in research due to their high affinity and specificity compared to those from other species. Rabbit IgG Fc-specific antibodies are particularly valuable as secondary detection tools in immunoassays (e.g., Western blotting, ELISA, immunohistochemistry) to recognize rabbit primary antibodies. They are often conjugated to enzymes (HRP, AP) or fluorophores for signal amplification. Additionally, these antibodies serve as critical reagents in studying Fc-mediated interactions, immune complex formation, or therapeutic antibody engineering.

In therapeutic contexts, rabbit anti-Fc antibodies may be employed to analyze pharmacokinetics, monitor biologics, or modulate Fc-related functions in drug development. They are typically produced by immunizing hosts (e.g., goats, donkeys) with purified rabbit IgG Fc fragments, followed by affinity purification. Cross-reactivity with IgG from other species is minimal, ensuring specificity. Recent advances include recombinant formats (e.g., monoclonal versions) to enhance reproducibility for standardized applications.