Hsp90 beta抗体;Hsp90 beta Antibody—艾普蒂

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     Western blot analysis of Hsp90 beta in Hela, mouse Brain tissue, rat Brain tissue lysates using Hsp90 beta antibody    

  
  

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     Immunofluorescence analysis of Hsp90 beta in mouse spleen tissue using Hsp90 beta antibody(red),and DAPI (blue).    

  
  

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     Immunofluorescence analysis of Hsp90 beta in rat lung tissue using HSP90β antibody(red),and DAPI (blue).    

  
  

Hsp90 beta (Heat Shock Protein 90 beta), encoded by the *HSP90AB1* gene, is a constitutively expressed cytosolic isoform of the Hsp90 family of molecular chaperones. It plays a critical role in maintaining cellular homeostasis by assisting in the folding, stabilization, and activation of client proteins, including signaling kinases, transcription factors, and steroid hormone receptors. Unlike its stress-inducible counterpart Hsp90 alpha, Hsp90 beta is expressed under normal physiological conditions and is essential for cell viability.

Antibodies targeting Hsp90 beta are widely used in research to study its expression, localization, and interactions in various biological contexts. They are crucial tools in techniques like Western blotting, immunohistochemistry, and immunoprecipitation, enabling insights into Hsp90 beta’s involvement in cancer progression, neurodegenerative diseases, and inflammatory responses. Dysregulation of Hsp90 beta has been linked to tumorigenesis, as it stabilizes oncoproteins, making it a potential therapeutic target. However, its role in specific diseases often requires differentiation from Hsp90 alpha due to their structural similarities.

Commercial Hsp90 beta antibodies are typically validated for specificity using knockout controls or siRNA-mediated knockdown. Recent studies also explore its extracellular roles in immune modulation and as a biomarker in certain pathologies. Research on Hsp90 beta inhibitors, though less advanced than those targeting Hsp90 alpha, highlights its unique contributions to cellular pathways and disease mechanisms.