IKB beta抗体;IKB beta Antibody—艾普蒂 新品

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     Immunohistochemistry analysis of paraffin-embedded Human Lung Carcinoma using IKB beta antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.    

  
  

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     Immunohistochemical analysis of paraffin-embedded Human tonsils using IKB beta antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.    

  
  

The IκBβ antibody is a crucial tool in studying the NF-κB signaling pathway, which regulates inflammation, immune responses, and cell survival. IκBβ (Inhibitor of κB beta) belongs to the IκB family of proteins that bind to NF-κB transcription factors, sequestering them in the cytoplasm and preventing DNA binding. Unlike IκBα, which is rapidly degraded upon stimulation (e.g., cytokines, pathogens), IκBβ exhibits delayed degradation and unique regulatory roles. It forms complexes with specific NF-κB subunits (e.g., p50/p65) and can sustain or modulate NF-κB activity in certain contexts, contributing to prolonged inflammatory responses or resolving signaling dynamics.

Antibodies targeting IκBβ enable researchers to detect protein expression, phosphorylation status, and subcellular localization via techniques like Western blotting, immunofluorescence, or immunoprecipitation. These tools are vital for investigating diseases linked to NF-κB dysregulation, such as chronic inflammation, autoimmune disorders, and cancers. IκBβ-specific antibodies help distinguish its functions from other IκB isoforms, particularly in studies exploring tissue-specific signaling or feedback mechanisms. For example, IκBβ’s role in feedback inhibition of NF-κB in macrophages or its interplay with IκBε in lymphoid cells highlights its unique biological relevance. Commercial IκBβ antibodies are typically validated for specificity across human, mouse, and rat models, supporting translational research. Understanding IκBβ dynamics remains critical for developing targeted therapies to modulate NF-κB pathways in disease contexts.