Desmin抗体;Desmin Antibody—艾普蒂

+ +

•  

   

     Immunohistochemistry analysis of paraffin-embedded mouse Skeletal Muscle Tissue using Desmin antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.    

  
  

•  

   

     Immunohistochemical analysis of paraffin-embedded Human tonsils using Desmin antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.    

  
  

Desmin is a type III intermediate filament protein predominantly expressed in muscle cells, including skeletal, cardiac, and smooth muscle. It plays a critical role in maintaining structural integrity, mechanical stability, and functional coordination of the cytoskeleton by linking Z-discs in sarcomeres, connecting myofibrils to organelles, and stabilizing cell membranes. Desmin also facilitates force transmission and organelle positioning during muscle contraction.

Desmin antibodies are essential tools in research and diagnostics for identifying muscle-specific pathologies. In research, they help study desmin-related myopathies (desminopathies), caused by mutations in the *DES* gene, leading to abnormal protein aggregation, muscle weakness, and cardiomyopathy. These antibodies are also used to investigate desmin's roles in cell signaling, muscle regeneration, and fibrosis.

In diagnostics, desmin antibodies are employed in immunohistochemistry to distinguish myogenic tumors (e.g., rhabdomyosarcoma) from other neoplasms, as desmin is a reliable marker of muscle differentiation. They aid in confirming diagnoses of degenerative muscle disorders, inflammatory myopathies, or cardiac diseases. Additionally, desmin expression changes are studied in conditions like muscular dystrophy, heart failure, and atherosclerosis.

Overall, desmin antibodies provide insights into muscle biology and disease mechanisms, bridging cellular structure to clinical pathology. Their specificity makes them indispensable for both experimental and diagnostic applications in neuromuscular and cardiovascular research.