KIF7抗体;KIF7 Antibody—艾普蒂 新品

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     Immunofluorescence analysis of KIF7 in mouse colon using KIF7 antibody(red),and DAPI (blue).    

  
  

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     Immunohistochemistry analysis of paraffin-embedded mouse Kidney tissue using KIF7 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.    

  
  

The KIF7 antibody is a crucial tool for studying the Kinesin family member 7 (KIF7) protein, a conserved component of the Hedgehog (Hh) signaling pathway. KIF7. a microtubule-associated motor protein, regulates Hh signaling by acting as both a transcriptional regulator and a negative modulator of Gli transcription factors. It plays essential roles in embryonic development, tissue patterning, and cilia function. Dysregulation of KIF7 is implicated in developmental disorders (e.g., Joubert syndrome, acrocallosal syndrome) and cancers (e.g., medulloblastoma, basal cell carcinoma), making it a target for therapeutic research.

KIF7 antibodies enable the detection and localization of KIF7 in various experimental models. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein expression levels, subcellular distribution (particularly in primary cilia), and post-translational modifications. Species-specific variants (e.g., human, mouse) allow cross-species studies. Researchers also employ these antibodies to investigate KIF7's interaction partners and its role in ciliary trafficking or Hh signal transduction. Validation of antibody specificity remains critical due to structural similarities among kinesin family proteins. Recent studies focus on KIF7's dual regulatory mechanisms and its potential as a biomarker or therapeutic target, driving demand for high-quality, well-characterized antibodies with minimal batch-to-batch variability.