Phospho-PKC epsilon (Ser729)抗体;Phospho-PKC epsilon (Ser729) Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07485(TAC1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P07485(TAC1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The Phospho-PKC epsilon (Ser729) antibody is a specialized tool used to detect the activated form of Protein Kinase C epsilon (PKCε), a member of the serine/threonine kinase family. PKCε plays critical roles in cellular signaling pathways regulating cell survival, proliferation, and stress responses. Its activation typically involves phosphorylation and translocation to cellular membranes. The Ser729 phosphorylation site, located within the catalytic domain, is associated with kinase activation and downstream signaling. This phosphorylation event is implicated in diverse physiological processes, including cardioprotection during ischemia, neuronal function, and immune regulation, as well as pathological conditions like cancer, diabetes, and neurodegenerative diseases.

The antibody specifically recognizes PKCε phosphorylated at Ser729. enabling researchers to study its activation status in various experimental models. It is widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess PKCε signaling dynamics in response to stimuli like growth factors, oxidative stress, or pharmacological agents. Studies utilizing this antibody have clarified PKCε's role in cardiac preconditioning, where its activation mitigates ischemic damage, and in cancer progression, where it promotes tumor cell survival and metastasis.

Validated for specificity in multiple species and sample types, this antibody serves as a key reagent for investigating PKCε's context-dependent functions and its potential as a therapeutic target. Its application continues to advance understanding of cell signaling mechanisms in health and disease.